Buprenorphine-Naloxone Attrition Prediction Web App

Age at BUP-NAL Initiation:

Age at which the patient started BUP-NAL treatment. Age must be between 16-95 years

Opioid Dependence (Diagnosis):

Opioid dependence is a diagnosis for chronic use of opioids leading to dependence.

Limb Swelling (Diagnosis):

Limb swelling, as commonly seen in conditions such as deep vein thrombosis, heart failure, and chronic kidney disease.

Laxative Use:

Indicates whether the patient has used laxatives. Constipation is a common complication of opioid use.

Long-Acting Opioid Use:

Use of long-acting opioids such as Oxycodone Extended Release for pain management.

Prescribed Acetaminophen:

Typically a marker for sicker or more complicated patients as most use would be over-the-counter.

Chronic Pain:

Long-lasting pain that persists for weeks to years.

Liver Disease:

Any disorder that affects the function of the liver.

12-Lead ECG (within 90 days of initiation):

A common procedure for complicated patients, usually performed within 90 days prior to initiation.

Prescribed Diphenhydramine:

Diphenhydramine (Benadryl) often used for itch relief due to high-dose opioids, especially in a hospital setting.

Docusate (Laxative):

A stool softener, not highly effective but commonly prescribed for constipation management.

Opioid Withdrawal (before initiation):

Symptoms before starting buprenorphine-naloxone.

Prescribed Aspirin:

Typically prescribed as a marker for complex cases where it’s noted in EMR.

Major Depressive Disorder (Diagnosis):

Mood disorder causing persistent sadness and loss of interest.

Stabilization on Buprenorphine doses XX-XX mg:

Indicates stabilization on buprenorphine within the specified dose range.

Prediction Result

This section presents the predicted retention probability over time for a patient, along with comparative reference curves:

Patient Prediction: The predicted retention probability curve for the patient based on their input features.
High Risk (2.5th Percentile): Represents a reference curve indicating lower retention probabilities associated with patients at higher risk of treatment attrition.
Low Risk (97.5th Percentile): Represents a reference curve showing higher retention probabilities associated with patients expected to stay longer in treatment.
Median: Shows a curve that represents the median retention probability across the sample population for comparison.